MHC II (HLA-DQ)(SPV-L3), CF555 conjugate, 0.1mg/mL

Expédié par OZYME

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Type SKU Price HT Quantity
  • 500 μl
BTMBNC550200-500
  • 100 μl
BTMBNC550200-100

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General Information
Description Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones. Primary antibodies are available purified, or with a selection of fluorescent CF&reg; dyes and other labels. CF&reg; dyes offer exceptional brightness and photostability. See the <a href="https://biotium.com/wp-content/uploads/2013/07/CF-Dye-Brochure.pdf" target="_blank" rel="noopener">CF&reg; Dye Selection Guide</a> for more information. Note: Conjugates of blue fluorescent dyes like CF&reg;405S and CF&reg;405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<div><strong>Stock status:</strong> Because Biotium offers a large number of antibody and conjugation options, primary antibody conjugates may be made to order. Typical lead times are up to one week for CF® dye and biotin conjugates, and up to 2-3 weeks for fluorescent protein and enzyme conjugates. Please email <a href="mailto:order@biotium.com">order@biotium.com</a> to inquire about stock status and lead times before placing your order.</div>&nbsp; <strong>Catalog number key for antibody number 0200, Anti-MHC-II (SPV-L3)</strong>&nbsp;[table id=253 /]

Product Information

Purchasing Information
Certification RUO
French code (NACRES) NA.44
UNSPSC code 41105331
Human origin No
Target Details
MW target protein (kDa) 60 kDa
Identification
NCBI (gene ID) 3117
Brand
Brand Biotium
Product properties
Supplier category 1 Primary
Clonality Monoclonal
Clone SPV-L3
Concentration 0.1 mg/mL
Conjugate / tag CF555
Host Mouse
Immunogen T4-positive CTL clone HG-38
Isotype (antibody class) IgG2a, kappa
Validated reactivity Human , Porcine
Technical presentation https://biotium.com/product/monoclonal-anti-mhc-ii-hla-dq-spv-l3
Usage
Shelf-life (months) 24
Shipping temperature Room temperature
Dilution for application Immunofluorescence 0.5-1 ug/mL
Storage temperature 2 - 8 °C
Applications IF (ImmunoFluorescence) , FC (FACS)
Research area Immunology

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