WT1 (Wilm's Tumor 1)(WT1/857), CF660C conjugate, 0.1mg/mL

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Type SKU Price HT Quantity
  • 100 μl
BTMBNC600857-100
  • 500 μl
BTMBNC600857-500

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General Information
Description Recognizes a 47-55 kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors.WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas. Primary antibodies are available purified, or with a selection of fluorescent CF&reg; dyes and other labels. CF&reg; dyes offer exceptional brightness and photostability. See the <a href="https://biotium.com/wp-content/uploads/2013/07/CF-Dye-Brochure.pdf" target="_blank" rel="noopener">CF&reg; Dye Selection Guide</a> for more information. Note: Conjugates of blue fluorescent dyes like CF&reg;405S and CF&reg;405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<div><strong>Stock status:</strong> Because Biotium offers a large number of antibody and conjugation options, primary antibody conjugates may be made to order. Typical lead times are up to one week for CF® dye and biotin conjugates, and up to 2-3 weeks for fluorescent protein and enzyme conjugates. Please email <a href="mailto:order@biotium.com">order@biotium.com</a> to inquire about stock status and lead times before placing your order.</div>&nbsp; <strong>Catalog number key for antibody number 0857, Anti-Wilm&#039;s Tumor 1 (WT1/857)</strong>&nbsp;[table id=253 /]

Product Information

Purchasing Information
Certification RUO
French code (NACRES) NA.44
UNSPSC code 41105331
Human origin No
Target Details
MW target protein (kDa) 47-55 kDa
Identification
NCBI (gene ID) 7490
Brand
Brand Biotium
Product properties
Supplier category 1 Primary
Clonality Monoclonal
Clone WT1/857
Concentration 0.1 mg/mL
Conjugate / tag CF660C
Host Mouse
Immunogen Recombinant human WT1 protein
Isotype (antibody class) IgG
Validated reactivity Human , Mouse , Rat
Technical presentation https://biotium.com/product/monoclonal-anti-wt1-wilms-tumor-1-wt1857
Usage
Shelf-Life (months) 24
Shipping temperature Room temperature
Dilution for application Immunohistology formalin-fixed 0.5-1 ug/mL
Storage temperature 2-8°C
Applications IF (ImmunoFluorescence) , IHC-Paraffin (paraffin tissues) , FC (FACS)
Research area Cancer

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