Rabbit anti-CIZ1 Ab, Affinity Purified

Expédié par OZYME

Conditionnement SKU Prix HT Quantité
  • 100 μl (1 mg/ml)
  • 100 μl (10 blots)
  • 20 μl (2 blots)

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General Information

CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.

Informations produit

Purchasing Information
Certification RUO
French code (NACRES) NA.41
UNSPSC code 12352203
Country of origin (manufacturing) US
EU customs code 30021010
Vendor country US
Human origin No
Target Details
Other names CDKN1A-interacting zinc finger protein 1, cip1-interacting zinc finger protein, LSFR1, NP94, nuclear protein NP94, zinc finger protein 356, ZNF356
Immunogen sequence between 848 and 898
NCBI (gene ID) 25792
Uniprot Q9ULV3
Brand Bethyl Laboratories
Product properties
Supplier category 1 Primary Antibodies
Videos - tutorials https://yris.ozyme.fr/bet-video-tuto
Marketing brochures https://www.bethyl.com/content/resources
Datasheet/manual https://www.bethyl.com/content/protocols
Supplier category 3 PAB
MSDS https://www.bethyl.com/product/sds/A301-497A_SDS.pdf
Supplier category 2 Primary Antibodies
Type of Ig Whole molecule IgG (H+L)
Clonality Polyclonal
Conjugate / tag non conjugated
Host Rabbit
Immunogen between 848 and 898
isotype (antibody class) IgG
Technical presentation http://www.bethyl.com/product/A301-497A
Validated reactivity Human
Recombinant antibodies No
Shelf-Life (months) 12
Shipping temperature +4°C
Storage temperature +4°C
Applications IP ( Immuno Precipitation) , WB (Western Blot)

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